Salbutamol enantiomers: early clinical evidence in humans.
نویسنده
چکیده
منابع مشابه
Effects of salbutamol and enantiomers on allergen-induced asthmatic reactions and airway hyperreactivity.
Salbutamol consists of a racemic mixture of R- and S-salbutamol. R-salbutamol (levalbuterol) is the active bronchodilating enantiomer, whereas S-salbutamol is thought to be pharmacologically inactive or to exert adverse effects. This study evaluated the bronchoprotective effects of inhalation of therapeutically relevant doses of the racemate and individual enantiomers in guinea pigs. It was fou...
متن کاملRapid determination of salbutamol in pharmaceutical preparations by chiral capillary electrophoresis.
A fast and simple method of chiral capillary electrophoresis (CE) has been applied to the analysis of salbutamol in different pharmaceutical preparations. Using of a 25 mM acetate buffer (pH 5.0), containing 13.1 mg/mL carboxymethyl-beta-cyclodextrin (CM-beta-CD), an applied voltage of 20 kV and a temperature of 25 degrees C, the enantiomers of salbutamol could be separated in about 2 min. Thre...
متن کاملDiscrimination of prohibited oral use of salbutamol from authorized inhaled asthma treatment.
BACKGROUND The administration of salbutamol is permitted only by inhalation by the International Olympic Committee (IOC) for the management of asthma and exercise-induced asthma in athletes. The establishment of criteria to distinguish between the (IOC) authorized use (inhaled) and the (IOC) prohibited use (oral) of salbutamol appeared possible using simultaneous evaluation of variables based o...
متن کاملCOMPARISION OF THE EFFICACY OF NEBULIZED L-EPINEPHRINE, SALBUTAMOLAND NORMAL SALINE IN ACUTE BRONCHIOLITIS: A RANDOMIZED CLINICAL TRIAL
ABSTRACT Background: Acute bronchiolitis is the most common form of lower respiratory tract infection in infancy. There are numerous contradictory reports regarding the efficacy of nebulized bronchodilators in the management of infants with acute bronchiolitis. This study was designed to compare the efficacy of nebulized epinephrine with salbutamol for treatment of the disease. Methods: In a r...
متن کاملEffect of single doses of S-salbutamol, R-salbutamol, racemic salbutamol, and placebo on the airway response to methacholine.
BACKGROUND Commercially available salbutamol is a racemic mixture consisting of equal amounts of the two enantiomers, R-salbutamol and S-salbutamol, felt to be active and inert, respectively. METHODS A double blind, randomised, four way, crossover study was performed in 12 well controlled asthmatic subjects (forced expiratory volume in one second (FEV1) > 70% predicted, no beta 2 agonists for...
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ورودعنوان ژورنال:
- Thorax
دوره 52 10 شماره
صفحات -
تاریخ انتشار 1997